Colorado at Miami 12:10 PM ET
Cal Quantrill spent 2024 helping the Colorado Rockies win games. On Wednesday, he will try to stop them from sweeping their first series of 2025 when the Miami Marlins host the Rockies in the finale of their three-game series.
Milwaukee at Cincinnati 12:40 PM ET
Following a game-saving, homer-robbing catch to end the Tuesday night game, TJ Friedl and the Cincinnati Reds will try to accomplish another rarity against the visiting Milwaukee Brewers in the rubber game of the three-game series Wednesday afternoon.
LA Angels at Boston 1:35 PM ET
The visiting Los Angeles Angels will be attempting to sweep the Boston Red Sox on Wednesday afternoon when the teams complete their three-game series.
Houston at Pittsburgh 6:40 PM ET
Despite having their rotation decimated by injuries, the Houston Astros are on top of the American League West.
Chi. Cubs at Washington 6:45 PM ET
The visiting Chicago Cubs go for their fourth straight win when they play the Washington Nationals in the middle game of their series Wednesday night.
Cleveland at NY Yankees 7:05 PM ET
Jazz Chisholm Jr. received an ovation before his first at-bat Tuesday night, and he later delivered the biggest hit in the latest win for the New York Yankees.
Philadelphia at Toronto 7:07 PM ET
Philadelphia Phillies right-hander Mick Abel has given himself a tough act to follow for his second career major league start Wednesday night against the host Toronto Blue Jays.
Arizona at Atlanta 7:15 PM ET
Two veteran pitchers will square off Wednesday night when the Atlanta Braves host the Arizona Diamondbacks in the second game of their three-game series.
Texas at Tampa Bay 7:35 PM ET
Tampa Bay's Junior Caminero will look to continue his torrid hitting when the Rays chase a series victory over the visiting Texas Rangers on Wednesday night.
Detroit at Chi. White Sox 7:40 PM ET
Detroit Tigers right-hander Sawyer Gipson-Long is set to end a 615-day hiatus from the majors on Wednesday night when he starts against the host Chicago White Sox.
Baltimore at Seattle 9:40 PM ET
A lot has happened to the Baltimore Orioles since Colton Cowser last appeared in a game.
San Diego at San Francisco 9:45 PM ET
One day after the San Francisco Giants sent a message that offensive help could soon be on the way, the San Diego Padres hope their own prospect can contribute again as they go for a third straight road win on Wednesday night.
Minnesota at Athletics 10:05 PM ET
Willi Castro has never been viewed as having a power bat over his seven big league seasons, but he's suddenly displaying plenty of strength.