Michigan St. at Penn St. 6:30 PM ET
This season's first matchup between Michigan State and Penn State was heavily one-sided, in favor of the Spartans.
Georgia Tech at Notre Dame 7:00 PM ET
It's been nearly two years since Notre Dame won back-to-back ACC games.
Miami-Florida at Clemson 7:00 PM ET
Following a week of historic road wins, Clemson returns home to face free-falling Miami in Atlantic Coast Conference play on Wednesday night.
Xavier at Seton Hall 7:00 PM ET
In late December, Seton Hall absorbed a 20-point loss at Xavier and responded with five straight wins.
Iowa at Maryland 8:30 PM ET
Iowa and Maryland have contrasting strengths and weaknesses, but both teams are struggling to sustain success ahead of their Big Ten meeting on Wednesday in College Park, Md.
South Carolina at Auburn 8:30 PM ET
Two weeks ago, South Carolina was unranked.
Connecticut at DePaul 9:00 PM ET
Top-ranked UConn is set to visit Big East cellar dweller DePaul on Wednesday night in a bid to extend its conference winning streak to 13 games and an overall run against the Blue Demons to 17.
Tennessee at Arkansas 9:00 PM ET
Tennessee coach Rick Barnes sees no lasting impact on his team after a rare double-digit loss going into Wednesday night's matchup against Southeastern Conference foe Arkansas in Fayetteville, Ark.
Oregon St. at Arizona State 9:00 PM ET
Arizona State looks to continue its home dominance of Oregon State when the two Pac-12 schools meet on Wednesday night at Tempe, Ariz.